pentobarbital will minimize the extent or influence of buprenorphine buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.Observe Intently (one)pentobarbital will decrease the extent or effect of tofacitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Loss of, or lessened response to